Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures
When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
John Wiley & Sons Ltd and The Anatomical Society
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29960/ http://umpir.ump.edu.my/id/eprint/29960/7/Physical%20fitness%20in%20community-dwelling%20older.pdf |
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| author | Castro-Mejía, Josué L. Khakimov, Bekzod Krych, Lukasz Bülow, Jacob Bechshøft, Rasmus L. Hojfeldt, Grith Mertz, Kenneth H. Garne, Eva Stahl Schacht, Simon R. Hajar Fauzan, Ahmad Kot, Witold Hansen, Lars H. Perez-Cueto, Federico J. A. Lind, Mads V. Lassen, Aske J. Tetens, Inge Jensen, Tenna Reitelseder, Soren Jespersen, Astrid P. Holm, Lars Engelsen, Soren B. Nielsen, Dennis S. |
| author_facet | Castro-Mejía, Josué L. Khakimov, Bekzod Krych, Lukasz Bülow, Jacob Bechshøft, Rasmus L. Hojfeldt, Grith Mertz, Kenneth H. Garne, Eva Stahl Schacht, Simon R. Hajar Fauzan, Ahmad Kot, Witold Hansen, Lars H. Perez-Cueto, Federico J. A. Lind, Mads V. Lassen, Aske J. Tetens, Inge Jensen, Tenna Reitelseder, Soren Jespersen, Astrid P. Holm, Lars Engelsen, Soren B. Nielsen, Dennis S. |
| author_sort | Castro-Mejía, Josué L. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65Â years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging. |
| first_indexed | 2025-11-15T02:56:34Z |
| format | Article |
| id | ump-29960 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:56:34Z |
| publishDate | 2020 |
| publisher | John Wiley & Sons Ltd and The Anatomical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-299602020-11-13T08:21:11Z http://umpir.ump.edu.my/id/eprint/29960/ Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures Castro-Mejía, Josué L. Khakimov, Bekzod Krych, Lukasz Bülow, Jacob Bechshøft, Rasmus L. Hojfeldt, Grith Mertz, Kenneth H. Garne, Eva Stahl Schacht, Simon R. Hajar Fauzan, Ahmad Kot, Witold Hansen, Lars H. Perez-Cueto, Federico J. A. Lind, Mads V. Lassen, Aske J. Tetens, Inge Jensen, Tenna Reitelseder, Soren Jespersen, Astrid P. Holm, Lars Engelsen, Soren B. Nielsen, Dennis S. QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine RC1200 Sports Medicine When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65Â years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging. John Wiley & Sons Ltd and The Anatomical Society 2020 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/29960/7/Physical%20fitness%20in%20community-dwelling%20older.pdf Castro-Mejía, Josué L. and Khakimov, Bekzod and Krych, Lukasz and Bülow, Jacob and Bechshøft, Rasmus L. and Hojfeldt, Grith and Mertz, Kenneth H. and Garne, Eva Stahl and Schacht, Simon R. and Hajar Fauzan, Ahmad and Kot, Witold and Hansen, Lars H. and Perez-Cueto, Federico J. A. and Lind, Mads V. and Lassen, Aske J. and Tetens, Inge and Jensen, Tenna and Reitelseder, Soren and Jespersen, Astrid P. and Holm, Lars and Engelsen, Soren B. and Nielsen, Dennis S. (2020) Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. Aging Cell, 19 (3). pp. 1-13. ISSN 1474-9726. (Published) https://doi.org/10.1111/acel.13105 https://doi.org/10.1111/acel.13105 |
| spellingShingle | QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine RC1200 Sports Medicine Castro-Mejía, Josué L. Khakimov, Bekzod Krych, Lukasz Bülow, Jacob Bechshøft, Rasmus L. Hojfeldt, Grith Mertz, Kenneth H. Garne, Eva Stahl Schacht, Simon R. Hajar Fauzan, Ahmad Kot, Witold Hansen, Lars H. Perez-Cueto, Federico J. A. Lind, Mads V. Lassen, Aske J. Tetens, Inge Jensen, Tenna Reitelseder, Soren Jespersen, Astrid P. Holm, Lars Engelsen, Soren B. Nielsen, Dennis S. Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| title | Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| title_full | Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| title_fullStr | Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| title_full_unstemmed | Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| title_short | Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| title_sort | physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures |
| topic | QR Microbiology RA0421 Public health. Hygiene. Preventive Medicine RC1200 Sports Medicine |
| url | http://umpir.ump.edu.my/id/eprint/29960/ http://umpir.ump.edu.my/id/eprint/29960/ http://umpir.ump.edu.my/id/eprint/29960/ http://umpir.ump.edu.my/id/eprint/29960/7/Physical%20fitness%20in%20community-dwelling%20older.pdf |