The effects of antifoam agent on dead end filtration process
The formation of foam as a result from introducing gases during cell culture process in the bioprocess industry has indirectly affected the throughput of the product of interest. Due to that, antifoams were developed and established as one of the means to minimize the formation of foam in the cell c...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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IOP Publishing
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/7/The%20Effects%20of%20Antifoam%20Agent%20on%20Dead%20End%20Filtration%20Process.pdf |
| _version_ | 1848821710297497600 |
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| author | Syazana, Mohamad Pauzi Normadyzah, Ahmad M. F., Yahya Mohd Azmir, Arifin |
| author_facet | Syazana, Mohamad Pauzi Normadyzah, Ahmad M. F., Yahya Mohd Azmir, Arifin |
| author_sort | Syazana, Mohamad Pauzi |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The formation of foam as a result from introducing gases during cell culture process in the bioprocess industry has indirectly affected the throughput of the product of interest. Due to that, antifoams were developed and established as one of the means to minimize the formation of foam in the cell culture. There are many types of antifoams but the silicone-type of antifoams are widely used in the bioprocess industry. Although the establishment of antifoam has aided the cell culture process, the impacts of its presence in the cell culture to the downstream process especially the dead end filtration is not widely discussed. The findings in the study emphasized on the dead end filtration performance that includes flux rate profile and the resulted filtration capacity. In this study, the concentrations of antifoam injected into the solution were varied from 0.2% v/v – 1.0% v/v and the solutions were filtered using constant flow method. The resulted maximum pressure readings and final flux rates indicated that the resistance exerted to the feed flow rate increased as the concentration of antifoam loaded in the solution increased. This later has led to the decline in the flux rates with percentage reduction between 32 – 68%. The calculated filter capacity for flux rate of 1000LMH ranged from 53 – 63L/m2 while it is in the range of 40 – 43L/m2 for flux rate of 2000LMH. The presence of antifoam agents in the feed load was determined to have negative effects on the dead end filtration performance and it may reduce the efficiency of the dead end filtration process. |
| first_indexed | 2025-11-15T02:29:40Z |
| format | Conference or Workshop Item |
| id | ump-23020 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:29:40Z |
| publishDate | 2018 |
| publisher | IOP Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-230202024-01-10T07:39:43Z http://umpir.ump.edu.my/id/eprint/23020/ The effects of antifoam agent on dead end filtration process Syazana, Mohamad Pauzi Normadyzah, Ahmad M. F., Yahya Mohd Azmir, Arifin TP Chemical technology The formation of foam as a result from introducing gases during cell culture process in the bioprocess industry has indirectly affected the throughput of the product of interest. Due to that, antifoams were developed and established as one of the means to minimize the formation of foam in the cell culture. There are many types of antifoams but the silicone-type of antifoams are widely used in the bioprocess industry. Although the establishment of antifoam has aided the cell culture process, the impacts of its presence in the cell culture to the downstream process especially the dead end filtration is not widely discussed. The findings in the study emphasized on the dead end filtration performance that includes flux rate profile and the resulted filtration capacity. In this study, the concentrations of antifoam injected into the solution were varied from 0.2% v/v – 1.0% v/v and the solutions were filtered using constant flow method. The resulted maximum pressure readings and final flux rates indicated that the resistance exerted to the feed flow rate increased as the concentration of antifoam loaded in the solution increased. This later has led to the decline in the flux rates with percentage reduction between 32 – 68%. The calculated filter capacity for flux rate of 1000LMH ranged from 53 – 63L/m2 while it is in the range of 40 – 43L/m2 for flux rate of 2000LMH. The presence of antifoam agents in the feed load was determined to have negative effects on the dead end filtration performance and it may reduce the efficiency of the dead end filtration process. IOP Publishing 2018-05-22 Conference or Workshop Item PeerReviewed pdf en cc_by http://umpir.ump.edu.my/id/eprint/23020/7/The%20Effects%20of%20Antifoam%20Agent%20on%20Dead%20End%20Filtration%20Process.pdf Syazana, Mohamad Pauzi and Normadyzah, Ahmad and M. F., Yahya and Mohd Azmir, Arifin (2018) The effects of antifoam agent on dead end filtration process. In: 3rd International Conference on Global Sustainability and Chemical Engineering, ICGSCE 2017 , 15-16 February 2017 , Marriot Hotel, Putrajaya; Malaysia. pp. 1-6., 358 (012038). ISSN 1757-8981 (Print), 1757-899X (Online) (Published) https://doi.org/10.1088/1757-899X/358/1/012038 |
| spellingShingle | TP Chemical technology Syazana, Mohamad Pauzi Normadyzah, Ahmad M. F., Yahya Mohd Azmir, Arifin The effects of antifoam agent on dead end filtration process |
| title | The effects of antifoam agent on dead end filtration process |
| title_full | The effects of antifoam agent on dead end filtration process |
| title_fullStr | The effects of antifoam agent on dead end filtration process |
| title_full_unstemmed | The effects of antifoam agent on dead end filtration process |
| title_short | The effects of antifoam agent on dead end filtration process |
| title_sort | effects of antifoam agent on dead end filtration process |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/7/The%20Effects%20of%20Antifoam%20Agent%20on%20Dead%20End%20Filtration%20Process.pdf |