5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-Fluorouracil carrier abbreviated as MC/5-FU for potential colorectal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021
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| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/1829/ http://eprints.sunway.edu.my/1829/1/Ronald%20Teow%205%20Fluorouacil%20carbohydrate%20polymer.pdf |
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| author | Yusefi, Mostafa Soon, M. L. K. Shameli, Kamyar Teow, Sin Yeang * Ali, Roshafima Rasit Siew, K. K. Chan, H. Y. Wong, Magdelyn Mei Theing * Lim, Wei Ling * Kuča, K. |
| author_facet | Yusefi, Mostafa Soon, M. L. K. Shameli, Kamyar Teow, Sin Yeang * Ali, Roshafima Rasit Siew, K. K. Chan, H. Y. Wong, Magdelyn Mei Theing * Lim, Wei Ling * Kuča, K. |
| author_sort | Yusefi, Mostafa |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-Fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. |
| first_indexed | 2025-11-14T21:18:39Z |
| format | Article |
| id | sunway-1829 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:39Z |
| publishDate | 2021 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-18292021-08-13T07:07:30Z http://eprints.sunway.edu.my/1829/ 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment Yusefi, Mostafa Soon, M. L. K. Shameli, Kamyar Teow, Sin Yeang * Ali, Roshafima Rasit Siew, K. K. Chan, H. Y. Wong, Magdelyn Mei Theing * Lim, Wei Ling * Kuča, K. RC0254 Neoplasms. Tumors. Oncology (including Cancer) Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-Fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. Elsevier 2021 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1829/1/Ronald%20Teow%205%20Fluorouacil%20carbohydrate%20polymer.pdf Yusefi, Mostafa and Soon, M. L. K. and Shameli, Kamyar and Teow, Sin Yeang * and Ali, Roshafima Rasit and Siew, K. K. and Chan, H. Y. and Wong, Magdelyn Mei Theing * and Lim, Wei Ling * and Kuča, K. (2021) 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment. Carbohydrate Polymers. p. 118523. ISSN 0144-8617 http://doi.org/10.1016/j.carbpol.2021.118523 doi:10.1016/j.carbpol.2021.118523 |
| spellingShingle | RC0254 Neoplasms. Tumors. Oncology (including Cancer) Yusefi, Mostafa Soon, M. L. K. Shameli, Kamyar Teow, Sin Yeang * Ali, Roshafima Rasit Siew, K. K. Chan, H. Y. Wong, Magdelyn Mei Theing * Lim, Wei Ling * Kuča, K. 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| title | 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| title_full | 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| title_fullStr | 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| title_full_unstemmed | 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| title_short | 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| title_sort | 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
| topic | RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.sunway.edu.my/1829/ http://eprints.sunway.edu.my/1829/ http://eprints.sunway.edu.my/1829/ http://eprints.sunway.edu.my/1829/1/Ronald%20Teow%205%20Fluorouacil%20carbohydrate%20polymer.pdf |