Insights into the antimicrobial potential of Dithiocarbamate anions and metal-based species
Bacterial infection remains a worldwide problem that requires urgent addressing. Overuse and poor disposal of antibacterial agents abet the emergence of bacterial resistance mechanisms. There is a clear need for new approaches for the development of antibacterial therapeutics. Herein, the antibacter...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2021
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/1786/ http://eprints.sunway.edu.my/1786/1/Tiekink%20Inorganics%202021%209%2048.pdf |
| _version_ | 1848802133957148672 |
|---|---|
| author | Yeo, Chien Ing * Tiekink, Edward R. T. * Chew, Jactty * |
| author_facet | Yeo, Chien Ing * Tiekink, Edward R. T. * Chew, Jactty * |
| author_sort | Yeo, Chien Ing * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Bacterial infection remains a worldwide problem that requires urgent addressing. Overuse and poor disposal of antibacterial agents abet the emergence of bacterial resistance mechanisms. There is a clear need for new approaches for the development of antibacterial therapeutics. Herein, the antibacterial potential of molecules based on dithiocarbamate anions, of general formula R(R’)NCS2(−), and metal salts of transition metals and main group elements, is summarized. Preclinical studies show a broad range of antibacterial potential, and these investigations are supported by appraisals of possible biological targets and mechanisms of action to guide chemical syntheses. This bibliographic review of the literature points to the exciting potential of dithiocarbamate-based therapeutics in the crucial battle against bacteria. Additionally, included in this overview, for the sake of completeness, is mention of the far fewer studies on the antifungal potential of dithiocarbamates and even less work conducted on antiparasitic behavior. |
| first_indexed | 2025-11-14T21:18:31Z |
| format | Article |
| id | sunway-1786 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:18:31Z |
| publishDate | 2021 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-17862021-08-30T08:12:14Z http://eprints.sunway.edu.my/1786/ Insights into the antimicrobial potential of Dithiocarbamate anions and metal-based species Yeo, Chien Ing * Tiekink, Edward R. T. * Chew, Jactty * QD Chemistry Bacterial infection remains a worldwide problem that requires urgent addressing. Overuse and poor disposal of antibacterial agents abet the emergence of bacterial resistance mechanisms. There is a clear need for new approaches for the development of antibacterial therapeutics. Herein, the antibacterial potential of molecules based on dithiocarbamate anions, of general formula R(R’)NCS2(−), and metal salts of transition metals and main group elements, is summarized. Preclinical studies show a broad range of antibacterial potential, and these investigations are supported by appraisals of possible biological targets and mechanisms of action to guide chemical syntheses. This bibliographic review of the literature points to the exciting potential of dithiocarbamate-based therapeutics in the crucial battle against bacteria. Additionally, included in this overview, for the sake of completeness, is mention of the far fewer studies on the antifungal potential of dithiocarbamates and even less work conducted on antiparasitic behavior. MDPI 2021-06 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/1786/1/Tiekink%20Inorganics%202021%209%2048.pdf Yeo, Chien Ing * and Tiekink, Edward R. T. * and Chew, Jactty * (2021) Insights into the antimicrobial potential of Dithiocarbamate anions and metal-based species. Inorganics, 9 (6). p. 48. ISSN 2304-6740 https://doi.org/10.3390/inorganics9060048 https://doi.org/10.3390/inorganics9060048 |
| spellingShingle | QD Chemistry Yeo, Chien Ing * Tiekink, Edward R. T. * Chew, Jactty * Insights into the antimicrobial potential of Dithiocarbamate anions and metal-based species |
| title | Insights into the antimicrobial potential of Dithiocarbamate
anions and metal-based species |
| title_full | Insights into the antimicrobial potential of Dithiocarbamate
anions and metal-based species |
| title_fullStr | Insights into the antimicrobial potential of Dithiocarbamate
anions and metal-based species |
| title_full_unstemmed | Insights into the antimicrobial potential of Dithiocarbamate
anions and metal-based species |
| title_short | Insights into the antimicrobial potential of Dithiocarbamate
anions and metal-based species |
| title_sort | insights into the antimicrobial potential of dithiocarbamate
anions and metal-based species |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/1786/ http://eprints.sunway.edu.my/1786/ http://eprints.sunway.edu.my/1786/ http://eprints.sunway.edu.my/1786/1/Tiekink%20Inorganics%202021%209%2048.pdf |