Emerging therapeutic roles of exosomes in HIV-1 infection
Exosomes are nanometer-sized vesicles derived from endosomes of a variety of cell types and could be found in various biological fluids. The contents of exosomes vary depending on the cellular origin and state of health. Exosomes are a form of vehicle to transmit information between cells, transport...
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| Format: | Book Section |
| Language: | English |
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Academic Press, Elsevier
2020
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| Online Access: | http://eprints.sunway.edu.my/1145/ http://eprints.sunway.edu.my/1145/1/Teow%20Sin%20Yeang%20chapter%207%20exosomes-1.pdf |
| _version_ | 1848801986564063232 |
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| author | Pang, Siew Wai * Teow, Sin Yeang * |
| author_facet | Pang, Siew Wai * Teow, Sin Yeang * |
| author_sort | Pang, Siew Wai * |
| building | SU Institutional Repository |
| collection | Online Access |
| description | Exosomes are nanometer-sized vesicles derived from endosomes of a variety of cell types and could be found in various biological fluids. The contents of exosomes vary depending on the cellular origin and state of health. Exosomes are a form of vehicle to transmit information between cells, transport wastes out of cells, and in the case of Human Immunodeficiency Virus Type 1 (HIV-1), promote infection and pathogenesis. HIV-1 and exosomes share many similarities in terms of lipid profile and protein make-up and could be the reason why the exosomal pathway is an effective route for HIV-1 to exploit. While exosomes have been shown in many instances to promote viral pathogenesis, there are also evidences that exosomes from specific cell origins could inhibit HIV-1, to a certain extent. This review summarizes the roles of exosome in promoting or inhibiting HIV-1 pathogenesis, as diagnostic biomarkers, therapeutic tools, and the challenges faced for its successful implementation in clinical applications. |
| first_indexed | 2025-11-14T21:16:10Z |
| format | Book Section |
| id | sunway-1145 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:16:10Z |
| publishDate | 2020 |
| publisher | Academic Press, Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | sunway-11452019-11-29T06:47:41Z http://eprints.sunway.edu.my/1145/ Emerging therapeutic roles of exosomes in HIV-1 infection Pang, Siew Wai * Teow, Sin Yeang * RM Therapeutics. Pharmacology Exosomes are nanometer-sized vesicles derived from endosomes of a variety of cell types and could be found in various biological fluids. The contents of exosomes vary depending on the cellular origin and state of health. Exosomes are a form of vehicle to transmit information between cells, transport wastes out of cells, and in the case of Human Immunodeficiency Virus Type 1 (HIV-1), promote infection and pathogenesis. HIV-1 and exosomes share many similarities in terms of lipid profile and protein make-up and could be the reason why the exosomal pathway is an effective route for HIV-1 to exploit. While exosomes have been shown in many instances to promote viral pathogenesis, there are also evidences that exosomes from specific cell origins could inhibit HIV-1, to a certain extent. This review summarizes the roles of exosome in promoting or inhibiting HIV-1 pathogenesis, as diagnostic biomarkers, therapeutic tools, and the challenges faced for its successful implementation in clinical applications. Academic Press, Elsevier 2020 Book Section PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1145/1/Teow%20Sin%20Yeang%20chapter%207%20exosomes-1.pdf Pang, Siew Wai * and Teow, Sin Yeang * (2020) Emerging therapeutic roles of exosomes in HIV-1 infection. In: Exosomes. Academic Press, Elsevier, Oxford, UK, pp. 147-178. ISBN 9780128160534 http://doi.org/10.1016/B978-0-12-816053-4.00007-9 doi:10.1016/B978-0-12-816053-4.00007-9 |
| spellingShingle | RM Therapeutics. Pharmacology Pang, Siew Wai * Teow, Sin Yeang * Emerging therapeutic roles of exosomes in HIV-1 infection |
| title | Emerging therapeutic roles of exosomes in HIV-1 infection |
| title_full | Emerging therapeutic roles of exosomes in HIV-1 infection |
| title_fullStr | Emerging therapeutic roles of exosomes in HIV-1 infection |
| title_full_unstemmed | Emerging therapeutic roles of exosomes in HIV-1 infection |
| title_short | Emerging therapeutic roles of exosomes in HIV-1 infection |
| title_sort | emerging therapeutic roles of exosomes in hiv-1 infection |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.sunway.edu.my/1145/ http://eprints.sunway.edu.my/1145/ http://eprints.sunway.edu.my/1145/ http://eprints.sunway.edu.my/1145/1/Teow%20Sin%20Yeang%20chapter%207%20exosomes-1.pdf |