Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis...
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Wiley
2019
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| Online Access: | http://eprints.sunway.edu.my/1121/ http://eprints.sunway.edu.my/1121/1/Yasodha%20Chemistry%20%20Biodiversity-accepted%202019.pdf |
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| author | Loo, Kong Yong Leong, Kok Hoong Yasodha Sivasothy, * Halijah Ibrahim, Khalijah Awang, |
| author_facet | Loo, Kong Yong Leong, Kok Hoong Yasodha Sivasothy, * Halijah Ibrahim, Khalijah Awang, |
| author_sort | Loo, Kong Yong |
| building | SU Institutional Repository |
| collection | Online Access |
| description | The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis Ridl., was identified as an active dual inhibitor for α‐amylase (IC50=114.80 μm) and α‐glucosidase (IC50=153.87 μm). This is the first report on the dual α‐amylase and α‐glucosidase inhibitory activities of a bis‐labdanic diterpene. The Lineweaver‐Burk plots of compound 1 indicate that it is a mixed‐type inhibitor with regard to both enzymes. Based on molecular docking studies, compound 1 docked in a non‐active site of both enzymes. The dual inhibitory activity of compound 1 makes it a suitable natural alternative in the treatment of type 2 diabetes. |
| first_indexed | 2025-11-14T21:16:04Z |
| format | Article |
| id | sunway-1121 |
| institution | Sunway University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:16:04Z |
| publishDate | 2019 |
| publisher | Wiley |
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| spelling | sunway-11212019-11-15T01:45:48Z http://eprints.sunway.edu.my/1121/ Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. Loo, Kong Yong Leong, Kok Hoong Yasodha Sivasothy, * Halijah Ibrahim, Khalijah Awang, QD Chemistry The inhibition of carbohydrate‐hydrolyzing enzymes in human digestive organs is crucial in controlling blood sugar levels, which is important in treating type 2 diabetes. In the current study, pahangensin A (1), a bis‐labdanic diterpene characterized previously in the rhizomes of Alpinia pahangensis Ridl., was identified as an active dual inhibitor for α‐amylase (IC50=114.80 μm) and α‐glucosidase (IC50=153.87 μm). This is the first report on the dual α‐amylase and α‐glucosidase inhibitory activities of a bis‐labdanic diterpene. The Lineweaver‐Burk plots of compound 1 indicate that it is a mixed‐type inhibitor with regard to both enzymes. Based on molecular docking studies, compound 1 docked in a non‐active site of both enzymes. The dual inhibitory activity of compound 1 makes it a suitable natural alternative in the treatment of type 2 diabetes. Wiley 2019-06 Article PeerReviewed text en cc_by_nc_nd_4 http://eprints.sunway.edu.my/1121/1/Yasodha%20Chemistry%20%20Biodiversity-accepted%202019.pdf Loo, Kong Yong and Leong, Kok Hoong and Yasodha Sivasothy, * and Halijah Ibrahim, and Khalijah Awang, (2019) Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. Chemistry & Biodiversity, 16 (6). e1900032. ISSN 1612-1872 http://doi.org/10.1002/cbdv.201900032 doi:10.1002/cbdv.201900032 |
| spellingShingle | QD Chemistry Loo, Kong Yong Leong, Kok Hoong Yasodha Sivasothy, * Halijah Ibrahim, Khalijah Awang, Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. |
| title | Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. |
| title_full | Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. |
| title_fullStr | Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. |
| title_full_unstemmed | Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. |
| title_short | Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl. |
| title_sort | molecular insight and mode of inhibition of α ‐glucosidase and α ‐amylase by pahangensin a from alpinia pahangensis ridl. |
| topic | QD Chemistry |
| url | http://eprints.sunway.edu.my/1121/ http://eprints.sunway.edu.my/1121/ http://eprints.sunway.edu.my/1121/ http://eprints.sunway.edu.my/1121/1/Yasodha%20Chemistry%20%20Biodiversity-accepted%202019.pdf |