Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening
This study compares the diagnostic performance of urine and serum multiple biomarkers for early diagnosis of ovarian cancer. The sample population includes 119 benign and 101 ovarian cancer patients. The marker combinations used to compare performance include 16 markers whose concentration values we...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2015
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| Online Access: | http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/1/03_Hye-Jeong_Song.pdf |
| _version_ | 1848812105101213696 |
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| author | Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim |
| author_facet | Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim |
| author_sort | Hye, Jeong Song |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | This study compares the diagnostic performance of urine and serum multiple biomarkers for early diagnosis of ovarian cancer. The sample population includes 119 benign and 101 ovarian cancer patients. The marker combinations used to compare performance include 16 markers whose concentration values were obtained using the Luminex assay. In order to identify an optimal marker combination that could classify ovarian cancer and benign patients, the area under the curve (AUC) is used to evaluate 2-, 3-, and 4-marker combinations and the classification is performed by using logistic regression. In the case of urine samples, the best AUC values are 87.89% for the 2 protein markers combination, 90.22% for the 3 markers combination, and 92.43% for the 4 marker combination. In contrast, the best AUC values for serum sample are 92.4% for the 2 marker combination, 93.63% for the 3 marker combination and 94.63% for the 4 marker combination. This study confirmed that combining multiple biomarkers could improve diagnostic accuracy. Even though the urine sample shows relatively lower performance than serum, urine could be utilized more widely for its simple usability. |
| first_indexed | 2025-11-14T23:57:00Z |
| format | Article |
| id | oai:generic.eprints.org:9487 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:57:00Z |
| publishDate | 2015 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:94872016-12-14T06:50:05Z http://journalarticle.ukm.my/9487/ Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim This study compares the diagnostic performance of urine and serum multiple biomarkers for early diagnosis of ovarian cancer. The sample population includes 119 benign and 101 ovarian cancer patients. The marker combinations used to compare performance include 16 markers whose concentration values were obtained using the Luminex assay. In order to identify an optimal marker combination that could classify ovarian cancer and benign patients, the area under the curve (AUC) is used to evaluate 2-, 3-, and 4-marker combinations and the classification is performed by using logistic regression. In the case of urine samples, the best AUC values are 87.89% for the 2 protein markers combination, 90.22% for the 3 markers combination, and 92.43% for the 4 marker combination. In contrast, the best AUC values for serum sample are 92.4% for the 2 marker combination, 93.63% for the 3 marker combination and 94.63% for the 4 marker combination. This study confirmed that combining multiple biomarkers could improve diagnostic accuracy. Even though the urine sample shows relatively lower performance than serum, urine could be utilized more widely for its simple usability. Universiti Kebangsaan Malaysia 2015-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9487/1/03_Hye-Jeong_Song.pdf Hye, Jeong Song and Ki, Seok Jeong and Jong, Dae Kim and Chan, Young Park and Yu, Seop Kim (2015) Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening. Sains Malaysiana, 44 (12). pp. 1671-1676. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol44num12_2015/contentsVol44num12_2015.html |
| spellingShingle | Hye, Jeong Song Ki, Seok Jeong Jong, Dae Kim Chan, Young Park Yu, Seop Kim Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| title | Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| title_full | Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| title_fullStr | Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| title_full_unstemmed | Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| title_short | Performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| title_sort | performance comparison of serum and urine biomarkers from independent samples for ovarian cancer screening |
| url | http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/ http://journalarticle.ukm.my/9487/1/03_Hye-Jeong_Song.pdf |