Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization
Allergic contact dermatitis (ACD) is a highly prevalent allergic inflammatory dermatosis with persistent severe pruritus. Zhi-Yang-Fang (ZYF), a topical Chinese herbal compound used in clinical practice for treating ACD, has certain drawbacks such as inconvenience in use and its impact on aesthetics...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2024
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| Online Access: | http://journalarticle.ukm.my/24504/ http://journalarticle.ukm.my/24504/1/SS%2022.pdf |
| _version_ | 1848816120696406016 |
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| author | Li, Peiyang Zhao, Jianhao Wang, Junlin Nie, Hong |
| author_facet | Li, Peiyang Zhao, Jianhao Wang, Junlin Nie, Hong |
| author_sort | Li, Peiyang |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Allergic contact dermatitis (ACD) is a highly prevalent allergic inflammatory dermatosis with persistent severe pruritus. Zhi-Yang-Fang (ZYF), a topical Chinese herbal compound used in clinical practice for treating ACD, has certain drawbacks such as inconvenience in use and its impact on aesthetics. This research aimed to overcome these shortcomings by developing an F127/F68-based thermosensitive hydrogel containing ZYF aqueous extract and hyaluronic acid-chitosan quaternary ammonium salt (HA-HTCC) microspheres. The 19 major components of ZYF aqueous extract were preliminarily identified using ultra-high-performance liquid chromatography coupled to Quadrupole-Exactive Orbitrap mass spectrometry (UPLC-Q Exactive Orbitrap-MS) analysis. HA-HTCC microspheres and HA-HTCC microspheres containing ZYF aqueous extract were prepared using the physical cross-linking method, and the success of the preparation was confirmed through a series of characterisations. The concentration of F127 and F68 was screened. The proportions of each substance in the final hydrogel formulation were determined, prepared using the cold method, and characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and a rotational rheometer. These technologies verified the successful preparation, temperature sensitivity, and stability of the hydrogel. The hydrogel developed may be considered a promising approach for the management of ACD. |
| first_indexed | 2025-11-15T01:00:50Z |
| format | Article |
| id | oai:generic.eprints.org:24504 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:00:50Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:245042024-11-12T07:16:36Z http://journalarticle.ukm.my/24504/ Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization Li, Peiyang Zhao, Jianhao Wang, Junlin Nie, Hong Allergic contact dermatitis (ACD) is a highly prevalent allergic inflammatory dermatosis with persistent severe pruritus. Zhi-Yang-Fang (ZYF), a topical Chinese herbal compound used in clinical practice for treating ACD, has certain drawbacks such as inconvenience in use and its impact on aesthetics. This research aimed to overcome these shortcomings by developing an F127/F68-based thermosensitive hydrogel containing ZYF aqueous extract and hyaluronic acid-chitosan quaternary ammonium salt (HA-HTCC) microspheres. The 19 major components of ZYF aqueous extract were preliminarily identified using ultra-high-performance liquid chromatography coupled to Quadrupole-Exactive Orbitrap mass spectrometry (UPLC-Q Exactive Orbitrap-MS) analysis. HA-HTCC microspheres and HA-HTCC microspheres containing ZYF aqueous extract were prepared using the physical cross-linking method, and the success of the preparation was confirmed through a series of characterisations. The concentration of F127 and F68 was screened. The proportions of each substance in the final hydrogel formulation were determined, prepared using the cold method, and characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and a rotational rheometer. These technologies verified the successful preparation, temperature sensitivity, and stability of the hydrogel. The hydrogel developed may be considered a promising approach for the management of ACD. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/24504/1/SS%2022.pdf Li, Peiyang and Zhao, Jianhao and Wang, Junlin and Nie, Hong (2024) Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization. Sains Malaysiana, 53 (9). pp. 3183-3195. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num9_2024/contentsVol53num9_2024.html |
| spellingShingle | Li, Peiyang Zhao, Jianhao Wang, Junlin Nie, Hong Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| title | Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| title_full | Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| title_fullStr | Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| title_full_unstemmed | Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| title_short | Thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| title_sort | thermosensitive hydrogel containing chinese herbal compound extract and hyaluronic acid-chitosan quaternary ammonium salt microspheres for topical application: preparation and characterization |
| url | http://journalarticle.ukm.my/24504/ http://journalarticle.ukm.my/24504/ http://journalarticle.ukm.my/24504/1/SS%2022.pdf |