Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats
There is an on-going debate about medicinal use of kratom plant (Mitragyna speciosa (MS)) on whether it has beneficial or adverse effects. This study aimed to examine long-term weight-reducing effects, toxicity, and dopamine pathway activation of MS alkaloid extract on adult male Wistar rats. In...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/16917/ http://journalarticle.ukm.my/16917/1/19.pdf |
| _version_ | 1848814176697319424 |
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| author | Ekkasit Kumarnsit, Niwat Keawpradub, Narumon Sengnon, Juraithip Wungsintaweekul, Dania Cheaha, |
| author_facet | Ekkasit Kumarnsit, Niwat Keawpradub, Narumon Sengnon, Juraithip Wungsintaweekul, Dania Cheaha, |
| author_sort | Ekkasit Kumarnsit, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | There is an on-going debate about medicinal use of kratom plant (Mitragyna speciosa (MS)) on whether it has beneficial
or adverse effects. This study aimed to examine long-term weight-reducing effects, toxicity, and dopamine pathway
activation of MS alkaloid extract on adult male Wistar rats. In anorexic study, the rats were divided into 3 groups (n
= 10), receiving intragastric administration once a day for 19 weeks as control (distilled water), chronic (20 mg/kg
MS alkaloid extract) and withdrawal (20 mg/kg MS alkaloid extract for week 1-12 and distilled water for week 13-19)
groups. Body weights were measured daily, and blood samples were collected at the end of study for biochemical and
hematological tests. In immunohistochemistry, the effects of the extract (40 and 80 mg/kg) on the nucleus accumbens
(NAc) and striatum (STr) were determined by using Fos-like immunoreactivity. From week 2 to 19, the results showed a
significant reduction in body weight gain produced by the extract. Cessation of the treatment at week 12 did not result in a
rebound weight gain. Chronic MS alkaloid extract treatment significantly decreased non-fasting blood sugar, triglyceride,
uric acid and blood urea nitrogen (BUN). However, elevated SGOT may suggest possible hepatotoxicity. Chronic MS
alkaloid extract treatment also produced baseline levels for most of the hematological parameters except a decrease of
monocyte. In immunohistochemistry, the acute treatment did not induce Fos-like immunoreactivity in the NAc and STr.
These data demonstrated the beneficial effects of the MS alkaloid extract for possible treatment of metabolic syndromes
without toxicity and rewarding effect. |
| first_indexed | 2025-11-15T00:29:56Z |
| format | Article |
| id | oai:generic.eprints.org:16917 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:29:56Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:169172021-06-28T15:36:28Z http://journalarticle.ukm.my/16917/ Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats Ekkasit Kumarnsit, Niwat Keawpradub, Narumon Sengnon, Juraithip Wungsintaweekul, Dania Cheaha, There is an on-going debate about medicinal use of kratom plant (Mitragyna speciosa (MS)) on whether it has beneficial or adverse effects. This study aimed to examine long-term weight-reducing effects, toxicity, and dopamine pathway activation of MS alkaloid extract on adult male Wistar rats. In anorexic study, the rats were divided into 3 groups (n = 10), receiving intragastric administration once a day for 19 weeks as control (distilled water), chronic (20 mg/kg MS alkaloid extract) and withdrawal (20 mg/kg MS alkaloid extract for week 1-12 and distilled water for week 13-19) groups. Body weights were measured daily, and blood samples were collected at the end of study for biochemical and hematological tests. In immunohistochemistry, the effects of the extract (40 and 80 mg/kg) on the nucleus accumbens (NAc) and striatum (STr) were determined by using Fos-like immunoreactivity. From week 2 to 19, the results showed a significant reduction in body weight gain produced by the extract. Cessation of the treatment at week 12 did not result in a rebound weight gain. Chronic MS alkaloid extract treatment significantly decreased non-fasting blood sugar, triglyceride, uric acid and blood urea nitrogen (BUN). However, elevated SGOT may suggest possible hepatotoxicity. Chronic MS alkaloid extract treatment also produced baseline levels for most of the hematological parameters except a decrease of monocyte. In immunohistochemistry, the acute treatment did not induce Fos-like immunoreactivity in the NAc and STr. These data demonstrated the beneficial effects of the MS alkaloid extract for possible treatment of metabolic syndromes without toxicity and rewarding effect. Penerbit Universiti Kebangsaan Malaysia 2021-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16917/1/19.pdf Ekkasit Kumarnsit, and Niwat Keawpradub, and Narumon Sengnon, and Juraithip Wungsintaweekul, and Dania Cheaha, (2021) Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats. Sains Malaysiana, 50 (3). pp. 779-790. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil3_2021/KandunganJilid50Bil3_2021.html |
| spellingShingle | Ekkasit Kumarnsit, Niwat Keawpradub, Narumon Sengnon, Juraithip Wungsintaweekul, Dania Cheaha, Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats |
| title | Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats |
| title_full | Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats |
| title_fullStr | Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats |
| title_full_unstemmed | Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats |
| title_short | Anorectic effect, biochemical and hematological profiles of alkaloid extract from Mitragyna speciosa Korth. in rats |
| title_sort | anorectic effect, biochemical and hematological profiles of alkaloid extract from mitragyna speciosa korth. in rats |
| url | http://journalarticle.ukm.my/16917/ http://journalarticle.ukm.my/16917/ http://journalarticle.ukm.my/16917/1/19.pdf |