Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches

Background Many acute stroke trials have given neutral results. Sub-optimal statistical analyses may be failing to detect efficacy. Methods which take account of the ordinal nature of functional outcome data are more efficient. We compare sample size calculations for dichotomous and ordinal out...

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Bibliographic Details
Main Author: The Optimising Analysis of Stroke Trials Collaboration, OAST
Format: Article
Published: Blackwell Publishing 2008
Online Access:https://eprints.nottingham.ac.uk/889/