Molecular biology approaches to quantify subcellular localisation of mRNA therapeutics

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Molecular biology approaches to quantify subcellular localisation of mRNA therapeutics

Messenger RNA (mRNA) therapeutics hold promise for treating diverse diseases but face delivery challenges, as effective cytosolic entry and subsequent translation are limited by endosomal entrapment. Nanoparticles aid mRNA transport across cell membranes, yet only a fraction of mRNA escapes endosome...

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Bibliographic Details
Main Author:	Smart, Alfredo D.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2025
Subjects:	APEX2 proximity labelling APEX-RT-qPCR mRNA localisation mRNA trafficking mRNA therapeutics
Online Access:	https://eprints.nottingham.ac.uk/81355/

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