The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies

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The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies

Background: Disruption of the blood-brain barrier (BBB) contributes to various agerelated neurological disorders. Brain microvascular endothelial cells (BMECs) are the most critical components of the BBB, forming a tightly sealed yet selectively permeable monolayer to maintain central nervous system...

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Bibliographic Details
Main Author:	Ya, Jingyuan
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2025
Subjects:	Blood-brain barrier Brain microvascular endothelial cells Senescent cells Ageing process Senolytics p38MAPK
Online Access:	https://eprints.nottingham.ac.uk/80866/

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