Design, Synthesis, and Development of Novel Intracellular Allosteric Modulators of CXC Chemokine Receptor 1 and 2

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Design, Synthesis, and Development of Novel Intracellular Allosteric Modulators of CXC Chemokine Receptor 1 and 2

Chemokine receptors, CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2) play pivotal roles in various neutrophil-mediated inflammatory diseases, including COPD, asthma, and psoriasis. Additionally, evidence is mounting for the involvement of neutrophils and the CXCL8-CXCR1/2 axis...

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Bibliographic Details
Main Author:	Francis, Rhys
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	Chemokine GPCR CADD SBDD CXCR1 CXCR2 Homology modelling
Online Access:	https://eprints.nottingham.ac.uk/79820/

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