Structural studies of Von Willebrand Factor regulators for Thrombotic Thrombocytopenic Purpura.

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Structural studies of Von Willebrand Factor regulators for Thrombotic Thrombocytopenic Purpura.

Blood clotting requires an urgent and efficient response with von Willebrand factor (VWF) playing a major role through recruitment of platelets forming a haemostatic plug. VWF is a large multi-domain glycoprotein, with the A1 domain for platelet binding via Gp1bα and the A2 domain containing the cle...

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Bibliographic Details
Main Author:	Markham-Lee, Zoe Jade
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	blood clotting TTP ADAMTS13 VWF Nanobody X-ray Crystallography
Online Access:	https://eprints.nottingham.ac.uk/79450/

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