An integrated approach to understanding the architecture of DDX3-mediated HIV translation pre-initiation complex

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An integrated approach to understanding the architecture of DDX3-mediated HIV translation pre-initiation complex

HIV transcripts contain highly structured 5′ untranslated regions (5′ UTR), necessitating a non-canonical translation pre-initiation complex (PIC), to allow ribosomes to bind and carry out translation. The PIC uniquely comprises the human DEAD-box RNA helicase, DDX3, bound directly to the trans-acti...

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Bibliographic Details
Main Author:	Ward, Shannon Leigh
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	HIV Tat protein; Pre-initiation complex formation; DDX3; Trans-activation response RNA
Online Access:	https://eprints.nottingham.ac.uk/78378/

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