Universal sensors for identifying use-dependent intracellular allosteric modulators of G protein coupled receptors

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Universal sensors for identifying use-dependent intracellular allosteric modulators of G protein coupled receptors

G protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors targeted by therapeutics. Their diverse signalling capabilities lead to involvement in a wide range of physiological and disease responses. The vast majority of molecules currently available to target GPCRs ar...

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Bibliographic Details
Main Author:	Farmer, James
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	G protein-coupled receptors; Allosteric mechanisms; Allosteric modulators; G protein derived peptidomimetics
Online Access:	https://eprints.nottingham.ac.uk/77576/

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