Investigations into β2-adrenoceptor pharmacology: kinetic analysis, mechanotransduction and allosteric modulation

QR Code

Investigations into β2-adrenoceptor pharmacology: kinetic analysis, mechanotransduction and allosteric modulation

The β2-adrenoceptor (β2AR) is a prototypical class A member of the G protein-coupled receptor (GPCR) superfamily of membrane-bound receptors. Activation of the β2AR is associated primarily with the relaxation of airway and vascular smooth muscle and has been targeted extensively by β-agonists to tre...

Full description

Bibliographic Details
Main Author:	Cullum, Sean A.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	β2-adrenoceptor; β2AR pharmacology; G protein- coupled receptor action; Pepducins
Online Access:	https://eprints.nottingham.ac.uk/77100/

Similar Items

The molecular basis of Gs protein efficacy at the b2- adrenoceptor
by: Harwood, Clare
Published: (2022)

Determination of the ligand pharmacophore required for secondary conformation activation of the human β1-adrenoceptor
by: Pinto de Sousa, Emanuel
Published: (2020)

Design, Synthesis, and Development of Novel Fluorescently Labelled Allosteric Probes for the Human Beta2-Adrenoceptor
by: Tuzer, Cemre
Published: (2023)

Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
by: Wilkinson, Daniel J., et al.
Published: (2017)

Similarity- and substructure-based development of β2-adrenergic receptor ligands based on unusual scaffolds
by: Schmidt, Denis, et al.
Published: (2017)

Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantative comparison of cellular and cardiovascular pharmacological responses
by: Baker, Jillian G., et al.
Published: (2011)

Molecular mechanisms controlling μ-opioid receptor activation
by: Batista Gondin, Arisbel
Published: (2019)

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease
by: Baker, Jillian G., et al.
Published: (2017)

Discovering the molecular basis for ligand pharmacological activity on β-adrenoceptors
by: Bunsuz, Asuman
Published: (2023)

Mechanisms of resistance to β-lactam antibiotics in Bacteroides species
by: Edwards, Richard
Published: (1995)

Design, synthesis and pharmacological evaluation of efficacy selective β2 adrenoceptor agonists
by: Lumb, Elliott
Published: (2019)

Adsorption kinetics and thermodynamics of water-insoluble crosslinked β-cyclodextrin polymer for phenol in aqueous solution
by: Huang, Hui, et al.
Published: (2013)

Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation
by: Pasini, Alice, et al.
Published: (2018)

β2-adrenoceptor gene polymorphisms and hypertension in African Trinidadians
by: Cross, Deborah Jane
Published: (2004)

Fabrication of β-cyclodextrin modified mesostructured silica coated multi-walled carbon nanotubes composites and application for paraben removal
by: Ding, Chuyuan, et al.
Published: (2018)

Characterisation of the native β-alanine pathway in Cupriavidus necator H16: an attractive route towards 3-hydroxypropionic acid production.
by: Orol Gómez, Diego
Published: (2020)

Universal sensors for identifying use-dependent intracellular allosteric modulators of G protein coupled receptors
by: Farmer, James
Published: (2024)

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents
by: Adams, James, et al.
Published: (2014)

The potential for repurposing α2-adrenoceptor agonists and noradrenaline uptake1 inhibitors in the management of septic shock
by: Benyamen, Julian
Published: (2024)

Identification, characterisation and functional analyses of novel beta-catenin associated protein, FLYWCH1
by: Muhammad, Belal Abdul-Rahman
Published: (2013)

Effect of encapsulation of D-limonene on the moisture adsorption property of ß-cyclodextrin
by: Fang, Zhongxiang, et al.
Published: (2013)

Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925
by: Conroy, Sean, et al.
Published: (2018)

Agonist stimulus trafficking by human prostanoid CRTH2 (DP2) receptors.
by: McArthur Wilson, Richard John
Published: (2007)

The design, synthesis and characterisation of subtype selective dipeptide-linked fluorescent ligands for human β1 and β2–adrenoceptors
by: Santu, L.T.
Published: (2017)

Molecular mechanism of GPCRs mediating metabolic responses – The role of adrenoceptors in glucose metabolism
by: Mukaida, Saori
Published: (2019)

Fabrication, characterization and evaluation of β-elemene nanoparticles for anti-cancer treatment
by: Zhao, Xi
Published: (2020)

Predictors of severe exacerbations, poor asthma control, and β-agonist overuse for patients with asthma
by: Patel, Mitesh, et al.
Published: (2014)

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors
by: van der Westhuizen, Emma T., et al.
Published: (2018)

Neuron-immune mechanisms contribute to pain in early stages of arthritis
by: Nieto, Francisco R., et al.
Published: (2016)

Engineering novel S-glycosidase activity into extremo-adapted β-glucosidase by rational design
by: Almulhim, Nourah
Published: (2021)

Novel hybrids of natural β-elemene bearing isopropanolamine moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility
by: Chen, Jichao, et al.
Published: (2017)

Some aspects on modelling of the β-phase depletion behaviour under different oxide growth kinetics in HVOF CoNiCrAlY coatings
by: Chen, H., et al.
Published: (2017)

Antioxidant properties of novel dimers derived from natural β‑elemene through inhibiting H2O2‑induced apoptosis
by: Chen, Jichao, et al.
Published: (2017)

In vivo pharmacological evaluation of a novel dual-target inhibitor and methylprednisolone as Alzheimer’s disease treatments
by: Zhang, Bocheng
Published: (2023)

A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of 1- adrenoceptors expressed in stable cell lines
by: Soave, Mark, et al.
Published: (2018)

Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility
by: Sevlever, Daniel, et al.
Published: (2015)

The role of extracellular signal-regulated kinase in beta-adrenoceptor-mediated vasodilatation
by: Uhiara, Chukwuemeka Obinna
Published: (2012)

Novel complementation biosensors to investigate G protein-coupled receptor kinetics and signalling bias
by: Dijon, Nicola C
Published: (2022)

Generation of human monoclonal antibodies: the development of methods to identify and isolate neutralising antibodies targeted to Ebolavirus from peripheral blood
by: Bailey, Graham D.
Published: (2017)

Impact of stirring speed on B-lactoglobulin fibril formation
by: Ng, Shy Kai, et al.
Published: (2016)