The safety pharmacology of Syk inhibitors: new preclinical screens to characterise cardiovascular adverse drug effects

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The safety pharmacology of Syk inhibitors: new preclinical screens to characterise cardiovascular adverse drug effects

Since the implementation of ICH S7A, the field of safety pharmacology has advanced radically. Current approaches for detection of cardiovascular (CV) adverse drug reactions (ADR), including evaluating mean arterial pressure (MAP) and heart rate (HR) often identify those safety risks. Nonetheless, hi...

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Bibliographic Details
Main Author:	Van Daele, Marieke
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	Safety pharmacology; adverse drug reactions; Symmetric Projection Attractor Reconstruction; Wave analysis; Cardiovascular side effects
Online Access:	https://eprints.nottingham.ac.uk/76890/

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