The safety pharmacology of Syk inhibitors: new preclinical screens to characterise cardiovascular adverse drug effects
Since the implementation of ICH S7A, the field of safety pharmacology has advanced radically. Current approaches for detection of cardiovascular (CV) adverse drug reactions (ADR), including evaluating mean arterial pressure (MAP) and heart rate (HR) often identify those safety risks. Nonetheless, hi...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2024
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| Online Access: | https://eprints.nottingham.ac.uk/76890/ |