Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis

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Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis

Introduction: Traction-dependent activation of the pro-fibrotic mediator transforming growth factor-β1 (TGF-β1), plays a critical role in idiopathic pulmonary fibrosis (IPF) pathogenesis. Galectin-3 potentiates TGF-β1 signaling to promote fibrogenesis and the efficacy of galectin inhibition in IPF p...

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Bibliographic Details
Main Author:	Calver, J.F.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2023
Subjects:	Pulmonary fibrosis fibroblast transforming growth factor beta (TGF‐β) integrin galectin
Online Access:	https://eprints.nottingham.ac.uk/76234/

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