Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
Introduction: Traction-dependent activation of the pro-fibrotic mediator transforming growth factor-β1 (TGF-β1), plays a critical role in idiopathic pulmonary fibrosis (IPF) pathogenesis. Galectin-3 potentiates TGF-β1 signaling to promote fibrogenesis and the efficacy of galectin inhibition in IPF p...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2023
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| Online Access: | https://eprints.nottingham.ac.uk/76234/ |