Effects of khat ethanol extract, cathinone and cathine on cytochrome P450 activities in vitro, molecular docking CYP-cathinone and CYP-cathine interactions and in vivo effects on Caenorhabditis elegans

QR Code

Effects of khat ethanol extract, cathinone and cathine on cytochrome P450 activities in vitro, molecular docking CYP-cathinone and CYP-cathine interactions and in vivo effects on Caenorhabditis elegans

Khat (Catha edulis Forsk), a natural amphetamine-like psychostimulant plant, and its major active compounds cathinone and cathine are consumed by many not only for cultural practice but also for its appetite suppressing effects and often co-abused with alcohols and polydrugs. Concurrent intake of he...

Full description

Bibliographic Details
Main Author:	Lim, Sharoen Yu Ming
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2024
Subjects:	khat cathinone cytochrome P450 (CYP) herb-drug interactions Caenorhabditis elegans (C. elegans)
Online Access:	https://eprints.nottingham.ac.uk/74441/

Similar Items

Toxicology studies in Caenorhabditis elegans
by: Budd, Chloe Denisha
Published: (2008)

Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development
by: Mora-Lorca, José Antonio, et al.
Published: (2016)

Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains
by: Bodhicharla, Rakesh, et al.
Published: (2012)

Remote automated multi-generational growth and observation of an animal in low Earth orbit
by: Oczypok, Elizabeth A., et al.
Published: (2012)

Exploring the effects of medicinal fungi on isolated bladder strips (ex vivo) and Caenorhabditis elegans (in vivo): focus on the caterpillar fungus, Ophiocordyceps sinensis
by: Pang, Li Yin
Published: (2024)

Genomic cloning and identification of a novel murine Cyp4a gene
by: Heng, Yee M.
Published: (1997)

In vitro study of modulatory effects of Strobilanthes crispus extracts on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) and CYP3A4
by: pan, Yan, et al.
Published: (2016)

Elucidating the neuropharmacological properties of the novel psychoactive substance and synthetic cathinone, mephedrone
by: O'Hara, Luke
Published: (2022)

Investigating the size-dependent toxicological effects of zinc oxide nanoparticles on Caenorhabditis elegans and the inhibitory potential of Cytochrome P450 isozymes
by: Chowdhury, Lamia Noushin Sadeque
Published: (2024)

Towards understanding latrophilin signalling in C.elegans
by: Al-Harbi, Hamad
Published: (2010)

Use of transgenic GFP reporter strains of the nematode Caenorhabditis elegans to investigate the patterns of stress responses induced by pesticides and by organic extracts from agricultural soils
by: Anbalagan, Charumathi, et al.
Published: (2013)

Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscle
by: Lehmann, Susann, et al.
Published: (2017)

Neuropharmacological properties of the cathinones
by: Shortall, S.E.
Published: (2015)

The reproductive biology and conservation of two rare Banksia species.
by: Barrett, Gregory J.
Published: (1985)

Identification and functional analysis of cyotochrome P450 from Bacillus lehensis G1
by: Ang, Swi See
Published: (2016)

Preparation, characterisation and applications : Boron nitride nanotubes (BNNTs), BNNTs-graphene hybrid and their polymer nanocomposites
by: Kakarla, Akesh Babu
Published: (2018)

Light-Induced Cytochrome c Redox Mediated Cell Killing
by: Potts, Jordan Cameron
Published: (2023)

Subcloning of cytochrome P450 2C19 (CYP2CL9) In escherichia coli strain BL21
by: Abdullah, Nur Azieyati
Published: (2011)

Theoretical and experimental evaluation of the effects of hydrostatic pressure on hepatocyte metabolic capacity
by: Burton, Lewis
Published: (2020)

Transgenic nematodes as biosensors for metal stress in soil pore water samples
by: Anbalagan, Charumathi, et al.
Published: (2012)

The role of NagC in Yersinia pestis and Yersinia pseudotuberculosis biofilm development and insect transmission
by: Elton, Linzy
Published: (2019)

Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells
by: Tuckey, R., et al.
Published: (2011)

Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells
by: Tuckey, R., et al.
Published: (2011)

Spaceflight and ageing: reflecting on Caenorhabditis elegans in space
by: Honda, Y., et al.
Published: (2014)

Caenorhabditis elegans-based analysis of Salmonella enterica
by: Khoo, Chai Hoon, et al.
Published: (2010)

What constitutes effective EP support for CYP with SEMH needs? Exploring SENCos’ post-coronavirus perspectives using Q-methodology.
by: Kershaw, Abigail Frances
Published: (2025)

Identification of genes conferring resistance to furan in Caenorhabditis elegans
by: Cai, Ning
Published: (2009)

Levels of acid sphingomyelinase (ASM) in Caenorhabditis elegans in microgravity
by: Gravely, Annabel, et al.
Published: (2018)

A pharmacogenetic study of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex 1 (VKORCl) / Immaculate Mbongo Langmia
by: Mbongo Langmia, Immaculate
Published: (2011)

Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review
by: Roberts, B., et al.
Published: (2023)

Characterisation of the effects of the food borne toxicant furan on Caenorhabditis elegans
by: Below, Cristina Catherine
Published: (2011)

Caenorhabditis elegans stress related gene responses to selected pesticides
by: Antoniou-Kourounioti, Melissa
Published: (2010)

Effect of the tocotrienol-rich fraction (TRF) on the healthspan of Caenorhabditis elegans
by: Tan, Tzer Sien, et al.
Published: (2021)

Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils.
by: Zakaria, Zainul Amiruddin, et al.
Published: (2011)

A review on CYP11A1, CYP17A1, and CYP19A1 polymorphism studies: candidate susceptibility genes for polycystic ovary syndrome (PCOS) and infertility
by: Heidarzadehpilehrood, Roozbeh, et al.
Published: (2022)

Population Pharmacokinetics Of Repaglinide In Healthy Subjects And Genetic Polymorphisms Of Cyp3a4 And Cyp2c8
by: Abu Bakar, Ruzilawati
Published: (2008)

Genetic polymorphisms of cyp3a4 and cyp2c8 in heal thy volunteers administered with repaglinide
by: Gan Siew, Hua
Published: (2008)

Expression of the Caenorhabditis elegans aryl hydrocarbon receptor ligand binding domain
by: Helaly, Ahmed
Published: (2011)

Prodigiosin Serratia marcescens tidak bersifat toksik terhadap Caenorhabditis elegans
by: Seah, Siew-Wei, et al.
Published: (2020)

Characterisation of equine cytochrome P450s
by: Orr, Catherine
Published: (2016)