Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer

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Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer

Colorectal cancer is the third most common cancer worldwide and ranks second for cancer-related mortality. Hypoxia (< 1% pO2) is found in up to 50% of colorectal tumours and is associated with poor patient prognosis, increased metastatic potential and resistance to therapy. Hypoxia stabilises the...

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Bibliographic Details
Main Author:	Thornton, Luke
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2023
Subjects:	Colorectal cancer; Hypoxia; Translation initiation factor; Metabolic mRNA translation; Hypoxia-induced metabolic reprogramming
Online Access:	https://eprints.nottingham.ac.uk/73892/

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