Investigating the functional properties of the multi-allelic copy number variable DEFA1A3 locus and their effects on gene expression and disease

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Investigating the functional properties of the multi-allelic copy number variable DEFA1A3 locus and their effects on gene expression and disease

Background Human α-defensins have important roles in innate immunity and exhibit antimicrobial properties against pathogens. The copy variable locus of human α-defensin genes - denoted as DEFA1A3 - is a multi-allelic copy number variable (CNV) region located on chr8p23.1. The DEFA1A3 CNV genes clus...

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Bibliographic Details
Main Author:	AlHamidi, Reem
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2023
Subjects:	Single nucleotide polymorphisms; Genetic polymorphisms; Periodontitis
Online Access:	https://eprints.nottingham.ac.uk/73133/

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