Investigating the functional properties of the multi-allelic copy number variable DEFA1A3 locus and their effects on gene expression and disease
Background Human α-defensins have important roles in innate immunity and exhibit antimicrobial properties against pathogens. The copy variable locus of human α-defensin genes - denoted as DEFA1A3 - is a multi-allelic copy number variable (CNV) region located on chr8p23.1. The DEFA1A3 CNV genes clus...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2023
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| Online Access: | https://eprints.nottingham.ac.uk/73133/ |