Development of the High Resolution Melt (HRM) method to detect the HLA-B*58:01 allele in order to prevent allopurinol-associated drug hypersensitivity

Development of the High Resolution Melt (HRM) method to detect the HLA-B*58:01 allele in order to prevent allopurinol-associated drug hypersensitivity

The HLA-B*58:01 allele was identified as a genetic marker for allopurinol-induced severe cutaneous adverse drug reactions (SCARs) in gout patients. Malaysia has a high frequency of 10.4% of the HLA-B*58:01 allele in allopurinol-induced SCARs patients. However, the strength of association of the HLA-...

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Bibliographic Details
Main Author: Nawoor, Anusha Devi
Format: Thesis (University of Nottingham only)
Language:English
Published: 2022
Subjects:
gout
allopurinol
SCARs
ADRs
High Resolution Melt (HRM) method
HLA-B*58:01
Online Access:https://eprints.nottingham.ac.uk/69403/

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