Development of the High Resolution Melt (HRM) method to detect the HLA-B*58:01 allele in order to prevent allopurinol-associated drug hypersensitivity
The HLA-B*58:01 allele was identified as a genetic marker for allopurinol-induced severe cutaneous adverse drug reactions (SCARs) in gout patients. Malaysia has a high frequency of 10.4% of the HLA-B*58:01 allele in allopurinol-induced SCARs patients. However, the strength of association of the HLA-...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2022
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| Online Access: | https://eprints.nottingham.ac.uk/69403/ |