Examining the mechanism of action of small-molecule negative allosteric modulators of the human chemokine receptor CXCR2

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Examining the mechanism of action of small-molecule negative allosteric modulators of the human chemokine receptor CXCR2

The CXC chemokine receptor 2 (CXCR2) is a G protein-coupled receptor (GPCR) with key functions in neutrophil trafficking and activation both during normal homeostasis, and in acute and chronic inflammation. In addition, CXCR2 signalling promotes tumour survival through the mediation of cell prolifer...

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Bibliographic Details
Main Author:	Nesheva, Desislava
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2022
Subjects:	Small-molecule Negative Allosteric Modulators Human Chemokine Receptor CXCR2
Online Access:	https://eprints.nottingham.ac.uk/69159/

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