Examining the mechanism of action of small-molecule negative allosteric modulators of the human chemokine receptor CXCR2
The CXC chemokine receptor 2 (CXCR2) is a G protein-coupled receptor (GPCR) with key functions in neutrophil trafficking and activation both during normal homeostasis, and in acute and chronic inflammation. In addition, CXCR2 signalling promotes tumour survival through the mediation of cell prolifer...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2022
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| Online Access: | https://eprints.nottingham.ac.uk/69159/ |