Genetic screens in intestinal organoid (mini-gut) culture using CRISPR-Cas-9 System and studying the role of FBXL5 in colorectal cancer cells
Current in vitro research methods are often difficult to translate into successful gene(s) functional and clinical applications. Immortalised cell lines are monocellular, 2-dimensional and do not accurately encapsulate the in vivo microenvironment, while in vivo animal models are often impractical,...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2022
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| Online Access: | https://eprints.nottingham.ac.uk/68697/ |