Can an inhibitor of a multidrug pump become a substrate?

QR Code

Can an inhibitor of a multidrug pump become a substrate?

ABCG2 is an ATP binding cassette (ABC) transporter that is involved in multidrug resistance, particularly anti-cancer drugs such as methotrexate and mitoxantrone. Distinguishing between substrates and inhibitors is important for rational design of drugs that won’t be transported by ABCG2 and inhibit...

Full description

Bibliographic Details
Main Author:	Hutchison, Ella
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2022
Subjects:	Multidrug resistance Inhibitor Substrate
Online Access:	https://eprints.nottingham.ac.uk/67260/

Similar Items

Isolation and characterization of novel phages in treating multidrug resistant Klebsiella pneumoniae using zebrafish larvae model
by: Assafiri, Omar
Published: (2020)

Elucidating the molecular mechanism of drug binding and translocation by the multidrug transporter ABCG2
by: Kapoor, Parth
Published: (2020)

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer
by: Daniel, Chloë, et al.
Published: (2013)

Multidrug resistant, extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm
by: Ibrahim, Delveen, et al.
Published: (2016)

On the intrinsic hardness of a metallic film/substrate system: Indentation size and substrate effects
by: Ma, Z., et al.
Published: (2012)

Antibiotic and Antimicrobial Metal Resistance in Escherichia coli from Livestock
by: Zhou, Weijie
Published: (2025)

Optimising laser stereolithography for constructing electronic packages onto novel substrates
by: Plant, Robert J.
Published: (2024)

Modelling multidrug resistance driven by efflux pump expression in Gram-negative bacteria
by: Youlden, George
Published: (2021)

Electrical properties of sulfonated polyaniline (Span) and polyaniline (Pani) polymers grown on conventional and high index GaAs substrates
by: Jameel, Dler Adil
Published: (2016)

Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study (IRIS)
by: Lina, Bruno, et al.
Published: (2018)

Methionine-aromatic interactions in ABCG2 influence mitoxantrone efflux
by: Azmir, Nur Amirah Hannan
Published: (2020)

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein
by: Mittra, Rituparna, et al.
Published: (2017)

Molecular cloning, functional assessment and transcriptome characterization of cysteine protease inhibitor and kunitz trypsin inhibitor from turmeric (Curcuma longa L.)
by: Chan, Seow Neng
Published: (2016)

Identification of lipase inhibitor from orthosiphon stamineus benth and analysis of lipase-inhibitor complex interaction
by: Alias, Norsyuhada
Published: (2016)

Multidrug-resistant tuberculosis during pregnancy and adverse birth outcomes: a systematic review and meta-analysis
by: Alene, Kefyalew, et al.
Published: (2021)

Proton pump inhibitor prescribing patterns in the UK: a primary care database study
by: Othman, Fatmah, et al.
Published: (2016)

P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism
by: Omar, Marhanis, et al.
Published: (2012)

Epidemiology of proton pump inhibitors therapy: an examination of the use and safety in general practice
by: Othman, Fatmah
Published: (2017)

Long-Term Proton Pump Inhibitor Therapy and Falls and Fractures in Elderly Women: A Prospective Cohort Study
by: Lewis, J.R., et al.
Published: (2014)

Sensitivities to DMI fungicides in populations of Podosphaera fusca in south central Spain
by: Lopez-Ruiz, Fran, et al.
Published: (2010)

Neuraminidase inhibitors: who, when, where?
by: Nguyen-Van-Tam, Jonathan S., et al.
Published: (2015)

Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
by: Li, Wenlong, et al.
Published: (2017)

Tuberculosis related disability: a systematic review and meta-analysis
by: Alene, Kefyalew, et al.
Published: (2021)

Electrochemical Synthesis, Characterisation, and Preliminary Biological Evaluation of an Anodic Aluminium Oxide Membrane with a pore size of 100 nanometres for a Potential Cell Culture Substrate
by: Poinern, Gerrard, et al.
Published: (2013)

The impact of oxytocin and GlyT1 inhibitors on social behaviour
by: Kohli, Shivali
Published: (2018)

Design and synthesis of small molecule inhibitors of coagulation FXIIa
by: Chen, Xi
Published: (2018)

The molecular binding interactions of inhibitors and activators of phosphoenolpyruvate carboxylase
by: Mancera, Ricardo, et al.
Published: (2005)

Distinct respiratory responses of soils to complex organic substrate are governed predominantly by soil architecture and its microbial community
by: Fraser, F.C., et al.
Published: (2016)

Investigating bisubstrate inhibitors of PRMT1 and CARM1
by: Gunnell, Emma
Published: (2019)

Evaluation of new chromogenic substrates for the detection of coliforms
by: Browne, Nicola, et al.
Published: (2010)

Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin
by: Robinson, Henry Duncan
Published: (2021)

Analysis of ABCG2 pharmacology and oligomerisation by solution based fluorescence correlation spectroscopy
by: Horsey, Aaron J.
Published: (2019)

α-Amidobenzylboronates and β-Ketobenzylboronates as Inhibitors of Plasma Kallikrein
by: Allison, Matthew
Published: (2024)

Natural products as a source of Coronavirus entry inhibitors
by: Szabó, Dávid, et al.
Published: (2024)

Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
by: Pallis, Monica, et al.
Published: (2013)

Synthesis of Potential Mycobacterium Tuberculosis InhA Inhibitors
by: Saleem, Tabrez Ali
Published: (2023)

Evaluation of inulin and aloe vera as green corrosion inhibitors for mild steel in 15% HCl
by: Ajayi, O.M, et al.
Published: (2016)

Reducing impulsivity in repeat violent offenders: an open label trial of a selective serotonin reuptake inhibitor
by: Butler, Tony, et al.
Published: (2010)

Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells
by: Sarwar, Martuza, et al.
Published: (2016)

Investigating challenges in producing adherent Boron Nitride PVD coatings for tooling and additive manufacturing applications
by: Cooper, Timothy Paul
Published: (2023)