Can an inhibitor of a multidrug pump become a substrate?
ABCG2 is an ATP binding cassette (ABC) transporter that is involved in multidrug resistance, particularly anti-cancer drugs such as methotrexate and mitoxantrone. Distinguishing between substrates and inhibitors is important for rational design of drugs that won’t be transported by ABCG2 and inhibit...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2022
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| Online Access: | https://eprints.nottingham.ac.uk/67260/ |