Development of a high-throughput screen for the study of CRISPR spacer acquisition
Bacteria are in an ever-evolving arms race to survive against invasion from foreign genetic elements. One mechanism of defence is the CRISPR-Cas system of adaptive immunity. Through CRISPR-Cas, cells store memories of previous invaders as DNA fragments, or spacers, in a genomic array of repeats. Onc...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2021
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| Online Access: | https://eprints.nottingham.ac.uk/66912/ |