The Development of Candidate Therapeutics for Transmissible Spongiform Encephalopathies

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The Development of Candidate Therapeutics for Transmissible Spongiform Encephalopathies

Previous studies have shown that addition of recombinant prion into a cell free prion replication assay – PMCA inhibits the formation of PrPSc. Previously naturally existing versions of ovine prion protein were tested: rARQ, rARR and rVRQ within this assay. Of these, rVRQ was the most potent inhibit...

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Bibliographic Details
Main Author:	Zolnierczyk, Katarzyna
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2021
Subjects:	spongiform encephalopathies prion diseases prion proteins
Online Access:	https://eprints.nottingham.ac.uk/65526/

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