The Development of Candidate Therapeutics for Transmissible Spongiform Encephalopathies
Previous studies have shown that addition of recombinant prion into a cell free prion replication assay – PMCA inhibits the formation of PrPSc. Previously naturally existing versions of ovine prion protein were tested: rARQ, rARR and rVRQ within this assay. Of these, rVRQ was the most potent inhibit...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2021
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| Online Access: | https://eprints.nottingham.ac.uk/65526/ |