An investigation into the function and mechanism of a GRK5-L41 polymorphism using human pluripotent cell-derived cardiomyocytes

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An investigation into the function and mechanism of a GRK5-L41 polymorphism using human pluripotent cell-derived cardiomyocytes

A single-nucleotide polymorphism (SNP) in G protein-coupled receptor kinase 5 (termed GRK5-Q41L) was reported to be associated with a low mortality rate for patients with heart failure and cardiac ischemia (Liggett et al., 2008). An in vitro study on transfected cells and transgenic mice suggested t...

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Bibliographic Details
Main Author:	Vo, Nguyen T. N.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2021
Subjects:	GRK5-L41 polymorphism; G proteins; Pluripotent Stem Cells; Heart cells; Cardiac model
Online Access:	https://eprints.nottingham.ac.uk/65137/

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