Targeting the hypoxic expression of epidermal growth factor receptor

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Targeting the hypoxic expression of epidermal growth factor receptor

Investigating translation regulation of epidermal growth factor receptor (EGFR) is a growing concern in the context of advanced breast cancer. The 5’ untranslated region (UTR) of EGFR mRNA contains an internal ribosome entry site (IRES) that permits hypoxic expression. This allows targeting of the e...

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Bibliographic Details
Main Author:	Alamoudi, Abdulmohsin
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2021
Subjects:	Breast cancer RNA DDX3 Antisense technology Hypoxia responsive polymers.
Online Access:	https://eprints.nottingham.ac.uk/64001/

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