The role of TET2 protein and oxidised forms of 5-methylcytosine in brain tumours

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The role of TET2 protein and oxidised forms of 5-methylcytosine in brain tumours

DNA methylation (5-methylcytosine, 5mC) is the major epigenetic modification involved in transcriptional regulation. Ten-eleven translocation (TET) proteins can enzymatically oxidise 5mC producing 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). According to seve...

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Bibliographic Details
Main Author:	Eleftheriou, Maria
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Brain tumours; DNA methylation; 5caC/5hmC; TET2; Pathogenesis; Tumorigenesis
Online Access:	https://eprints.nottingham.ac.uk/63635/

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