The role of TET2 protein and oxidised forms of 5-methylcytosine in brain tumours
DNA methylation (5-methylcytosine, 5mC) is the major epigenetic modification involved in transcriptional regulation. Ten-eleven translocation (TET) proteins can enzymatically oxidise 5mC producing 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). According to seve...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/63635/ |