Determination of the ligand pharmacophore required for secondary conformation activation of the human β1-adrenoceptor

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Determination of the ligand pharmacophore required for secondary conformation activation of the human β1-adrenoceptor

The β1-adrenergic receptor exists in at least two different agonist conformations: a primary conformation where endogenous catecholamines and β-blockers bind, and where agonist responses are blocked by low concentrations of antagonists and a secondary conformation, for which the precise nature is un...

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Bibliographic Details
Main Author:	Pinto de Sousa, Emanuel
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	G protein-coupled receptors(GPCR); β1-AR ; Alprenolol ; Oxprenolol
Online Access:	https://eprints.nottingham.ac.uk/63154/

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