Determination of the ligand pharmacophore required for secondary conformation activation of the human β1-adrenoceptor
The β1-adrenergic receptor exists in at least two different agonist conformations: a primary conformation where endogenous catecholamines and β-blockers bind, and where agonist responses are blocked by low concentrations of antagonists and a secondary conformation, for which the precise nature is un...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/63154/ |