Elucidating the molecular mechanism of drug binding and translocation by the multidrug transporter ABCG2
Many drug resistant tumours express one or more of the three main drug efflux transporters, P-glycoprotein (ABCB1), multidrug resistance protein 1 (MRP1; ABCC1) and breast cancer resistance protein (ABCG2). These transporters facilitate the export of diverse range of structurally unrelated compounds...
| Main Author: | |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/61418/ |