Investigation of molecular mechanisms regulating palmitate-induced metabolic inflexibility in a cell-based skeletal muscle model: physiological and pharmacological interventions.

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Investigation of molecular mechanisms regulating palmitate-induced metabolic inflexibility in a cell-based skeletal muscle model: physiological and pharmacological interventions.

Background Present evidence indicates that increased systemic circulating fatty acids following chronic high-fat dietary intake leads to skeletal muscle (SKM) metabolic inflexibility, and this is associated with an impairment of the mitochondrial pyruvate dehydrogenase complex (PDC) controlled c...

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Bibliographic Details
Main Author:	Chien, Hung-Che
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Molecular mechanisms Metabolic inflexibility Skeletal muscle metabolic inflexibility SKM
Online Access:	https://eprints.nottingham.ac.uk/61197/

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