Investigation of molecular mechanisms regulating palmitate-induced metabolic inflexibility in a cell-based skeletal muscle model: physiological and pharmacological interventions.
Background Present evidence indicates that increased systemic circulating fatty acids following chronic high-fat dietary intake leads to skeletal muscle (SKM) metabolic inflexibility, and this is associated with an impairment of the mitochondrial pyruvate dehydrogenase complex (PDC) controlled c...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/61197/ |