Integration of an in vitro renal cellular set of tools with systems biology modelling to predict the renal contribution to the pharmacokinetics of a drug

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Integration of an in vitro renal cellular set of tools with systems biology modelling to predict the renal contribution to the pharmacokinetics of a drug

The aim of this study was to develop an in vitro model of the kidney that could facilitate predictions of renal contribution to the pharmacokinetics drugs and to identify potential drug-drug interactions (DDIs). Porcine and murine proximal/distal tubule cells were grown as monolayers on Transwell fi...

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Bibliographic Details
Main Author:	Taylor, Patrick
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Kidney; In vitro model; Pharmacokinetics; Drug-drug interactions; Renal clearance
Online Access:	https://eprints.nottingham.ac.uk/60785/

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