Integration of an in vitro renal cellular set of tools with systems biology modelling to predict the renal contribution to the pharmacokinetics of a drug
The aim of this study was to develop an in vitro model of the kidney that could facilitate predictions of renal contribution to the pharmacokinetics drugs and to identify potential drug-drug interactions (DDIs). Porcine and murine proximal/distal tubule cells were grown as monolayers on Transwell fi...
| Main Author: | |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/60785/ |