A role for rebinding in the prevalence of on-target side effects of clinically used antipsychotics

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A role for rebinding in the prevalence of on-target side effects of clinically used antipsychotics

One explanation as to why atypical antipsychotic drugs (APDs e.g. clozapine) show reduced extrapyramidal side effects (EPS) involves their rapid dissociation from the dopamine D2 receptor (D2R). Their selective regional action in the brain permits an antipsychotic effect through inhibition of mesoli...

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Bibliographic Details
Main Author:	Sykes, David A
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	G protein coupled receptor Kinetics Association rate constant Dissociation rate constant Anti-psychotics Side effects Rebinding
Online Access:	https://eprints.nottingham.ac.uk/60636/

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