A role for rebinding in the prevalence of on-target side effects of clinically used antipsychotics
One explanation as to why atypical antipsychotic drugs (APDs e.g. clozapine) show reduced extrapyramidal side effects (EPS) involves their rapid dissociation from the dopamine D2 receptor (D2R). Their selective regional action in the brain permits an antipsychotic effect through inhibition of mesoli...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/60636/ |