New chemistry to support the search for more effective opioids
Herein is presented a synthesis route to obtain noroxymorphone, a vital intermediate in the manufacture of opioid medicines, using the major ingredient in opium – morphine as the starting material. Two steps of Albright-Goldman oxidation and the formation of diene are combined in one pot to enhance...
| Main Author: | |
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2020
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| Online Access: | https://eprints.nottingham.ac.uk/60621/ |
| _version_ | 1848799785173123072 |
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| author | Yang, Ruoyan |
| author_facet | Yang, Ruoyan |
| author_sort | Yang, Ruoyan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Herein is presented a synthesis route to obtain noroxymorphone, a vital intermediate in the manufacture of opioid medicines, using the major ingredient in opium – morphine as the starting material. Two steps of Albright-Goldman oxidation and the formation of diene are combined in one pot to enhance the efficiency of the whole route. The overall 14% yield is still impractical for industry. However, further optimization of Albright-Goldman oxidation can increase the yield to near 30% in total. Noroxymorphone is employed as a starting material to access new opioid derivatives by N-substitution or conjugate addition of amines onto electron-deficient alkenes. |
| first_indexed | 2025-11-14T20:41:11Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-60621 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:41:11Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-606212025-02-28T14:55:11Z https://eprints.nottingham.ac.uk/60621/ New chemistry to support the search for more effective opioids Yang, Ruoyan Herein is presented a synthesis route to obtain noroxymorphone, a vital intermediate in the manufacture of opioid medicines, using the major ingredient in opium – morphine as the starting material. Two steps of Albright-Goldman oxidation and the formation of diene are combined in one pot to enhance the efficiency of the whole route. The overall 14% yield is still impractical for industry. However, further optimization of Albright-Goldman oxidation can increase the yield to near 30% in total. Noroxymorphone is employed as a starting material to access new opioid derivatives by N-substitution or conjugate addition of amines onto electron-deficient alkenes. 2020-05-27 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/60621/1/Ruoyan%20Thesis%2014342401.pdf Yang, Ruoyan (2020) New chemistry to support the search for more effective opioids. MSc(Res) thesis, University of Nottingham. Noroxymorphone Opioid manufacture Albright-Goldman oxidation |
| spellingShingle | Noroxymorphone Opioid manufacture Albright-Goldman oxidation Yang, Ruoyan New chemistry to support the search for more effective opioids |
| title | New chemistry to support the search for more effective opioids |
| title_full | New chemistry to support the search for more effective opioids |
| title_fullStr | New chemistry to support the search for more effective opioids |
| title_full_unstemmed | New chemistry to support the search for more effective opioids |
| title_short | New chemistry to support the search for more effective opioids |
| title_sort | new chemistry to support the search for more effective opioids |
| topic | Noroxymorphone Opioid manufacture Albright-Goldman oxidation |
| url | https://eprints.nottingham.ac.uk/60621/ |