Human pluripotent stem cells derived-cardiomyocytes (hPSC-CMs) to assess the impact of drug- and gene-induced changes on cell function

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Human pluripotent stem cells derived-cardiomyocytes (hPSC-CMs) to assess the impact of drug- and gene-induced changes on cell function

The majority of data available for drug predictive safety and disease/polymorphism modelling are based on results from genetic association studies or from models other than humans, which can lead to conflicting mechanistic explanations. This thesis considers whether human pluripotent stem cell-deriv...

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Bibliographic Details
Main Author:	Mohd Yusof, Nurul Ain Nasim
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Drug safety screening; Human pluripotent stem cell-derived cardiomyocytes; Disease/polymorphism modelling; Cell function; Drug-induced changes
Online Access:	https://eprints.nottingham.ac.uk/60206/

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